Klinik für Psychische Gesundheit

This interest is reflected in the following topics:

• Pharmacogenomics and epigenomics
• Digital phenotyping of treatment response
• TMS and neurostimulation in Psychosis
• Early and first-time treatment of affective and non-affective psychosis
• Genetics and epigenetics of developmental processes of psychopathology in adolescence

Dr. Evelien Van Assche

Dipl.-Psych Teresa Vermillion

Dipl.-Psych Leonie Kiefer

Hr. Jan Greve (Medizindoktorandin)

SHKs

• Digital Phenotyping for Psychiatric Research; in Collaboration with ECNP
   
• CLOZIN: International Collaboration Studying phenotypic and molecular effects of Clozapin as an established antipsychotic treatment; in Collaboration with UMC Utrecht (NL).Website: Clozin study
   
• CARE-BMBF: Computer-assistierte Risiko-Evaluation in der Früherkennung psychotischer Erkrankungen. BMBF Project with focus on early psychosis management and prognosis. CARE
   
• STRATEGIES-Cohort. Gene-Environment Interactions and Epigenetics/Epigenomics in Adolescence; in Collaboration with Prof. Stephan Claes, KU Leuven (B).
   
• Molecular and cellular biobank for patients with psychosis

Internal funds

BMBF

Kendall, K. M., Van Assche, E., Andlauer, T. F. M., Choi, K. W., Luykx, J. J., Schulte, E. C., & Lu, Y. (2021). The genetic basis of major depression. Psychological Medicine, 1-14.

Okhuijsen-Pfeifer, C., Ayhan, Y., Lin, B. D., van Eijk, K. R., Bekema, E., Kool, L. J., ..., Van Assche, E., … & Luykx, J. J. (2020). Genetic susceptibility to clozapine-induced agranulocytosis/neutropenia across ethnicities: results from a new cohort of Turkish and other Caucasian participants, and meta-analysis. Schizophrenia Bulletin Open, 1(1), sgaa024.

Verhagen, M., Verweij, K. J., Lodder, G. M., Goossens, L., Verschueren, K., ..., Van Assche, E. & Vink, J. M. (2020). A SNP, gene, and polygenic risk score approach of oxytocin‐vasopressin genes in adolescents’ loneliness. Journal of Research on Adolescence, 30, 333-348.

Nelemans, S. A., Van Assche, E., Bijttebier, P., Colpin, H., Van Leeuwen, K., Verschueren, K., ... & Goossens, L. (2019). Parenting interacts with oxytocin polymorphisms to predict adolescent social anxiety symptom development: A novel polygenic approach. Journal of abnormal child psychology, 47(7), 1107-1120.

Van Assche, Evelien, et al. "Gene‐based interaction analysis shows GABA-ergic genes interacting with parenting in adolescent depressive symptoms." Journal of Child Psychology and Psychiatry 58.12 (2017): 1301-1309.