> Hartmann W. (PubMed), Huss S. (PubMed), Trautmann M. (PubMed) Wardelmann E. (PubMed)

Selected key publications:

Requirement for YAP1 signaling in myxoid liposarcoma.
Trautmann, M., Cheng, YY., Jensen, P., Azoitei, N., Brunner, I., Hüllein, J., Slabicki, M., Isfort, I., Cyra, M., Berthold, R., Wardelmann, E., Huss, S., Altvater, B., Rossig, C., Hafner, S., Simmet, T., Ståhlberg, A., Åman, P., Zenz, T., Lange, U., Kindler, T., Scholl, C., Hartmann, W., and Fröhling, S.
EMBO Molecular Medicine (2019), Published OnlineFirst March 21
DOI 10.15252/emmm.201809889 / PMID: 30898787 / Read more

SS18-SSX-dependent YAP/TAZ signaling in synovial sarcoma. Isfort, I., Cyra, M., Elges, S., Kailayangiri, S., Altvater, B., Rossig, C., Steinestel, K., Grünewald, I., Huss, S., Eßeling, E., Mikesch, JH., Hafner,S., Simmet, T., Wozniak, A., Schöffski, P., Larsson, OL., Wardelmann, E., Trautmann, M. and Hartmann, W.
Clinical Cancer Research (2019), Published OnlineFirst February 27
DOI: 10.1158/1078-0432.CCR-17-3553 / PMID: 30814111 / Read more

Phosphatidylinositol-3-kinase (PI3K)/Akt signaling is functionally essential in myxoid liposarcoma. Trautmann, M., Cyra, M., Isfort, I., Jeiler, B., Krüger, A., Grünewald, I., Steinestel, K., Altvater, B., Rossig, C., Hafner, S., Simmet, T., Becker, J., Åman, P., Wardelmann, E., Huss, S. and Hartmann, W.
Molecular Cancer Therapeutics (2019), Published OnlineFirst February 20
DOI: 10.1158/1535-7163.MCT-18-0763 / PMID: 30787173 / Read more

Activating mutations in the MAP‐kinase pathway define non‐ossifying fibroma of bone. Baumhoer, D., Kovac, M., Sperveslage, J., Ameline, B., Strobl, AC., Krause, A., Trautmann, M., Wardelmann, E., Nathrath, M., Höller, S., Hardes, J., Gosheger, G., Krieg, AH., Vieth, V., Tirabosco, R., Amary, F., Flanagan, AM., and Hartmann, W.
The Journal of Pathology (2018). First published: December 13
DOI: 10.1002/path.5216 / PMID: 30549028 / Read more

FUS-DDIT3 fusion protein driven IGF-IR signaling is a therapeutic target in myxoid liposarcoma. Trautmann, M., Menzel, J., Bertling, C., Cyra, M., Isfort, I., Steinestel, K., Elges, S., Grünewald, I., Altvater, B., Rössig, C., Fröhling, S., Hafner, S., Simmet, T., Åman, P., Wardelmann, E., Huss, S. and  Hartmann, W.
Clinical Cancer Research (2017), Published OnlineFirst July 28
DOI: 10.1158/1078-0432.CCR-17-0130 / PMID: 28637688 / Read more

MDM2 and CDK4 amplifications are rare events in salivary duct carcinomas. Grünewald, I., Trautmann, M., Busch, A., Bauer, L., Huss, S., Schweinshaupt, P., Vollbrecht, C., Odenthal, M., Quaas, A., Buttner, R., Meyer, M. F., Beutner, D., Huttenbrink, K. B., Wardelmann, E., Stenner, M., and Hartmann, W.
Oncotarget. 2016;7(46):75261-72
DOI: 10.18632/oncotarget.12127 / PMID: 27662657 / Read more

Deep sequencing in conjunction with expression and functional analyses reveals activation of FGFR1 in ewing sarcoma. Agelopoulos, K., Richter, G. H., Schmidt, E., Dirksen, U., von Heyking, K., Moser, B., Klein, H. U., Kontny, U., Dugas, M., Poos, K., Korsching, E., Buch, T., Weckesser, M., Schulze, I., Besoke, R., Witten, A., Stoll, M., Kohler, G., Hartmann, W., Wardelmann, E., Rossig, C., Baumhoer, D., Jurgens, H., Burdach, S., Berdel, W. E., and Muller-Tidow, C.
Clinical Cancer Research, 2015. 21(21):4935-46
DOI: 10.1158/1078-0432.CCR-14-2744 / PMID: 26179511 / Read more

SRC inhibition represents a potential therapeutic strategy in liposarcoma. Sievers, E., Trautmann, M., Kindler, D., Huss, S., Gruenewald, I., Dirksen, U., Renner, M., Mechtersheimer, G., Pedeutour, F., Aman, P., Nishio, J., Schildhaus, H. U., Kirfel, J., Schirmacher, P., Wardelmann, E., Buettner, R., and Hartmann, W.
International Journal of Cancer. 2015;137(11):2578-88
DOI: 10.1002/ijc.29645 / PMID: 26084847 / Read more

SS18-SSX fusion protein-induced Wnt/beta-catenin signaling is a therapeutic target in synovial sarcoma. Trautmann, M., Sievers, E., Aretz, S., Kindler, D., Michels, S., Friedrichs, N., Renner, M., Kirfel, J., Steiner, S., Huss, S., Koch, A., Penzel, R., Larsson, O., Kawai, A., Tanaka, S., Sonobe, H., Waha, A., Schirmacher, P., Mechtersheimer, G., Wardelmann, E., Buttner, R., and Hartmann, W.
Oncogene. 2014;33(42):5006-16
DOI: 10.1038/onc.2013.443 / PMID: 24166495 / Read more

SRC signaling is crucial in the growth of synovial sarcoma cells. Michels, S., Trautmann, M., Sievers, E., Kindler, D., Huss, S., Renner, M., Friedrichs, N., Kirfel, J., Steiner, S., Endl, E., Wurst, P., Heukamp, L., Penzel, R., Larsson, O., Kawai, A., Tanaka, S., Sonobe, H., Schirmacher, P., Mechtersheimer, G., Wardelmann, E., Buttner, R., and Hartmann, W.
Cancer Research. 2013;73(8):2518-28
DOI: 10.1158/0008-5472.CAN-12-3023 / PMID: 23580575 / Read more

Phosphatidylinositol-3'-kinase/AKT signaling is essential in synovial sarcoma. Friedrichs, N., Trautmann, M., Endl, E., Sievers, E., Kindler, D., Wurst, P., Czerwitzki, J., Steiner, S., Renner, M., Penzel, R., Koch, A., Larsson, O., Tanaka, S., Kawai, A., Schirmacher, P., Mechtersheimer, G., Wardelmann, E., Buettner, R., and Hartmann, W.
International Journal of Cancer. 2011;129(7):1564-75
DOI: 10.1002/ijc.25829 / PMID: 21128248 / Read more

Activation of phosphatidylinositol-3'-kinase/AKT signaling is essential in hepatoblastoma survival. Hartmann, W., Kuchler, J., Koch, A., Friedrichs, N., Waha, A., Endl, E., Czerwitzki, J., Metzger, D., Steiner, S., Wurst, P., Leuschner, I., von Schweinitz, D., Buettner, R., and Pietsch, T.
Clinical Cancer Research, 2009. 15(14):4538-45
DOI: 10.1158/1078-0432.CCR-08-2878 / PMID: 19584164 / Read more

Insulin-like growth factor-1 receptor acts as a growth regulator in synovial sarcoma. Friedrichs, N., Kuchler, J., Endl, E., Koch, A., Czerwitzki, J., Wurst, P., Metzger, D., Schulte, J. H., Holst, M. I., Heukamp, L. C., Larsson, O., Tanaka, S., Kawai, A., Wardelmann, E., Buettner, R., Pietsch, T., and Hartmann, W.
The Journal of Pathology, 2008. 216(4):428-39
DOI: 10.1002/path.2438 / PMID: 18855347 / Read more

Phosphatidylinositol 3'-kinase/AKT signaling is activated in medulloblastoma cell proliferation and is associated with reduced expression of PTEN. Hartmann, W., Digon-Sontgerath, B., Koch, A., Waha, A., Endl, E., Dani, I., Denkhaus, D., Goodyer, C. G., Sorensen, N., Wiestler, O. D., and Pietsch, T.
Clinical Cancer Research, 2006. 12(10):3019-27
DOI: 10.1158/1078-0432.CCR-05-2187 / PMID: 16707597 / Read more

Insulin-like growth factor II is involved in the proliferation control of medulloblastoma and its cerebellar precursor cells. Hartmann, W., Koch, A., Brune, H., Waha, A., Schuller, U., Dani, I., Denkhaus, D., Langmann, W., Bode, U., Wiestler, O. D., Schilling, K., and Pietsch, T.
American Journal of Pathology, 2005. 166(4):1153-62
DOI: 10.1016/S0002-9440(10)62335-8 / PMID:15793295 / Read more