Macrophages are myeloid cells with a variety of functions within the complex mucosal immune system. Of interest, (although being contrary processes), pathways involved in intestinal wound healing and inflammation-associated intestinal injury are both elicited by macrophages. We are investigating how, why and especially when macrophages process pro-inflammatory or pro-resolving properties during intestinal wound healing, and we are exploring new avenues to target macrophages to improve the outcome in intestinal inflammation, e.g. during Ulcerative colitis or Crohn’s disease.

Every inflammatory state is elicited by a variety of pathways connecting cellular and non-cellular components. We have focused on the crosstalk between leukocytes, platelets and the vascular endothelium and their role in the development and perpetuation of inflammation. Currently, we are testing the protective effect of sulforaphane, a naturally occurring isothiocyanate found in cruciferous vegetables (especially in broccoli). We are using real-time imaging to study interactions between leukocytes, platelets and the vascular endothelium.

Abstract