Klinik für Strahlentherapie – Radioonkologie




Hilgers K, Ibrahim SA, Kiesel L, Greve B, Espinoza-Sánchez NA, Götte M: Differential impact of membrane-bound and soluble forms of the prognostic marker Syndecan-1 on the invasiveness, migration, apoptosis and proliferation of cervicsl cancer cells. Frontiers in Oncology, 2022 https://doi.org/10.3389/fonc.2022.803899                                                              

Madanes et al: Resveratrol impairs cellular mechanisms associated with the pathogenesis of endometriosis. Reproductive BioMedicine Online 2022 (accepted)                


Ahmed SH, Espinoza-Sánches NA, El-Damen A, Fahim SA, Badawy MA, Greve B, El-Shinawi M, Götte M, Ibrahim SA: Small Extracellular Vesicle-encapsulated miR-181-5p, miR-222-3p and let-7a-5p: Next Generation Plasma Biopsy-based Diagnostic Biomarkers for Inflammatory Breast Cancer. PlosOne, 2021 doi: ·  https://doi.org/10.1371/journal.pone.0250642     

Valla S, Hassan N, Vitale DL, Madanes D, Spinelli FM, Teixeira FCOB, Greve B, Espinoza-Sanchez NA, Cristina C, Alaniz L *, Götte M*: Syndecan-1 depletion has a differential impact on hyaluronic acid metabolism and tumor cell behavior in luminal and triple-negative breast cancer cells. International Journal of Molecular Sciences, 2021 DOI: 10.3390/ijms22115874       

Kyriakopoulou K, Kefali E, Piperigkou Z, Riethmüller C, Greve B, Franchi M, Götte M, Kramanos N: EGFR is a pivotal player of the E2/ERβ-mediated functional properties, aggressiveness and stemness in triple-negative breast cancer cells. FEBS Journal, 2021 DOI: 10.1111/febs.16240

Troschel FM, Linsenmaier M, Borrmann K, Eich HT, Götte M, Greve B: Heparanase Expression is Associated With Cancer Stem Cell Features and Radioresistance in Hodgkin´s Lymphoma Cells. Anticancer Research 41 (7): 3299-3308, 2021 DOI: 10.21873/anticanres.15117 

Onyeisi JOS, Greve B, Espinoza-Sánchez NA, Kiesel L, Lopes CC, Götte M: microRNA-140-3p modulates invasiveness, motility, and extracellular matrix adhesionof breast cancer cells by targeting syndecan-4. J Cell Biochem. 2021 DOI: 10.1002/jcb.30071 

Troschel FM, Palenta H, Borrmann K, Heshe K, Hua SH, Yip GW, Kiesel L, Eich HT, Götte M, Greve B: Knockdown of the prognostic cancer stem cell marker Musashi-1 decreases radio-resistance while enhancing apoptosis in hormone receptor-positive breast cancer cells via p21WAF1/CIP1. J Cancer Res Clin Oncol 2021 DOI: 10.1007/s00432-021-03743-y 

Cocola C, Magnaghi V, Albeni E, Pelucchi P, Martino V, Vilardo L, Piscitelli E, Consiglio A, Grillo G, Mosca E, Gualtierotti R, Mazzaccaro D, La Sala G, Di Pietro C, Palizban M, Luini S, DePedro G, Morara S, Nano G, Kehler J, Greve B, Noghero A, Marazzitti D, Bussolino F, Bellinpanni G, Dágnano I, Götte M, Zucchi I, Reinbold R: Transmembrane-230 protein a Target of glioblastoma therapy. Frontiers in Cellular Neuroscience, section Cellular Neurophysiology 2021 https://doi.org/10.3389/fncel.2021.703431 

Löblein MT, Falke I, Eich HT, Greve B, Götte M, Troschel FM: Dual Knockdown of Musashi RNA-Binding Proteins MSI-1 and MSI-2 Attenuates Putative Cancer Stem Cell Characteristics and Therapy Resistance in Ovarian Cancer Cells. International Journal of Molecular Sciences 22 (21): 11502, 2021 https://doi.org/10.3390/ijms222111502 

Kahl I, Mense J, Finke C, Boller AL, Lorber C, Balázs G, Greve B, Götte M, Espinoza-Sánchesz NA: The cell cycle-related genes RHAMM, AURKA, TPX2, PLK1, and PLK4 are associated with the poor prognosis of breast cancer patients. Journal of Cellular Biochemistry 2021 https://doi.org/10.1002/jcb.30205 

Stejskalova A, Fincke V, Nowak M, Schmidt Y, Borrmann K, Von Walde MK, Schäfer SD, Kiesel L, Greve B, Götte M: Collagen I triggers collective migration and invasion in a 3D spheroid model of endometriotic lesions. Scientific Reports, 2021 doi: https://doi.org/10.1038/s41598-021-83645-8

Mc Cormack B, Greve B, Kiesel L, Meresman GF, Götte M, Baranao RI: The ellagic acid metabolites urolithin A and B differentially affect growth, adhesion, motility, and invasion of endometriotic cells in vitro. Human Reproduction, 2021, doi: 10.1093/humrep/deab053

Kuehn J, Espinoza-Sanchez NA, Teixeira FCOB, Pavao MSG, Kiesel L, Györffy B, Greve B, Götte M: Prognostic significance of hedgehog signaling network-related gene expression in breast cancer patients. Journal of Cellular Biochemistry, 2021 DOI: 10.1002/jch 29886

Nassar E, Hassan NYM, El-Ghonaimy EA, Hassan H, Abdullah MS, Rottke TV, Kiesel L, Greve B, Ibrahim SA, Götte M: Syndecan-1 promotes angiogenesis in triple-negative breast cancer through the prognostically relevant tissue factor pathway. Cancers, 2021 (accepted) 


Hassan N, Greve B, Espinoza-Sanchez NA, Götte M: Cell-surface heparan sulfate proteoglycans as multifunctional integrators of signaling in cancer. Cellular Signalling, 2020, doi.10.1016/j.cellsig.2020.109822

Katakam SK, Tria V, Sim WC, Yip GW, Molgora S, Karnavas T, Elghonaimy EA, Pelucchi P, Piscitelli E, Ibrahim SA, Zucchi I, Reinbold R, Greve B*, Götte M*: The heparan sulfate proteoglycan Syndecan-1 regulates colon cancer stem cell function via a focal adhesion kinase – Wnt signaling axis. FEBS Journal, 2020, (gemeinsame Letztautoren), doi: 10.1111/febs.15356           

Kumar A, Brezillon S, Untereiner V, Sockalingum G, Kumar S, Hossam M, Kemper B, Greve B, Mohr B, Ibrahim S, Goycoolea F, Kiesel L, Pavao M, Motta J, Götte M: HS2ST1-dependent signaling pathways determine breast cancer cell viability, matrix interactions and invasive behavior. Cancer Science, 2020, doi: 10.1111/cas.14539         

Fahim SA, Abdullah MS, Espinoza-Sánchez NA, Hassan H, Ibrahim AM, Ahmed SH, Shakir G, Badawy MA, Zakhary NI, Greve B, El-Shinawi M, Götte M, Ibrahim SA: Inflammatory Breast Carcinma: elevated miR-181-5p and reduced miR-200b-3p, miR-200c-3p and miR-203-3p expression as potential biomarkers with diagnostic value. Biomolecules, 2020 doi: 10.3390/biom10071059

Taxeira FCOB, Vijaya KA, Katakam SK, Cocola C, Pelucchi P, Graf M, Kiesel L, Reinbold R, Pavao MSG, Greve B, Götte M: The heparan sulfate sulfotransferases HS2ST1 and HS3ST2 are novel regulators of breast cancer stem-cell properties. Frontiers in Cell and Developmental Biology      (gemeinsame Letztautoren) doi: 10.3389/fcell.2020.559554      

Brand C, Greve B, Bölling T, Eich HT, Willich N, Harrach S, Hintelmann H, Lenz G, Mesters RM, Kessler T, Schliemann C Berdel WE, Schwöppe C: Radiation Synergizes with antitumor activity of CD13-targeted Tissue Factor in a HT1080 xenograft model of human soft tissue sarcoma. PlosOne, 15 (2), 2020 doi: 10.1371/journal.pone.0229271            

Elsayad K, Kroeger K, Greve B, Moustakis C, Assaf C, Stadler R, Lenz G, Weishaupt C, Eich HT: Low-dose total skin electron beam therapy: Quality of life improvement and clinical impact of maintenance and adjuvant treatment in patients with mycosis fungoides or Sezary syndrome. Strahlenther Onkol. 196(1):77-84, 2020 doi: 10.1007/s00066-019-01517-7

El-Nadi M, Hassan H, Saleh ME, Nassar E, Ismail YM, Amer M, Greve B, Götte M, El-Shinawi M, Ibrahim SA: Induction of heparanase via IL-10 correlates with a high infiltration of CD163- M2-type tumor-associated macrophages in inflammatory breast carcinomas. Matrix Biology Plus, 2020, Doi: 10.1016/j.mbplus.2020.100030                          

Manou D, Bouris P, Kletsas D, Götte M, Greve B, Moustakas A, Karamanos NK, Theocharis AD: Serglycin activates pro-tumorigenic signaling and controls glioblastoma cell stemness, differentiation and invasive potential. Matrix Biology Plus, 2020, Doi: 10.1016/ j.mbplus.2020.100033                           

Troschel FM, Minte A, Ismail YM, Kamal A, Abdullah MS, Ahmed SH, Deffner M, Kemper B, Kiesel L, Eich HT, Ibrahim SA, Götte M, Greve B: Knockdown of Musashi RNA Binding Proteins Decreases Radioresistance but Enhances Cell Motility and Invasion in Triple-Negative Breast Cancer. International Journal of Molecular Sciences, 21: 2169, 2020 doi 103390/ijms2162169                     

Katakam SK, Pelucchi P, Cocola C, Reinbold R, Vlodavsky I, Greve B*, Götte M*: Syndecan-1-dependent regulation of heparanase affects invasiveness, stem cell properties and therapeutic resistance of Caco2 colon cancer cells. Frontiers in Oncology, 2020 (*gemeinsame Letztautoren) doi: 10.3389/fonc.2020.00774


Ramirez WL, Brüggemann K, Hubert M, Achmad N, Kiesel L, Schäfer SD, Greve B, Götte M: Gamma-Secretase inhibition affects viability, apoptosis and the stem cell phenotype of endometriotic cells. Acta Obstet Gynecol Scand 2019, (gemeinsame Letztautoren) doi: 10.1111/aogs.13707

Weidner J, Hünger F, Odaibo G Olaleye D, Reichelt D, Greve B, Cassens U: Storage and Transportation of „HIV“ RNA in Plasma Samples up to 45 °C in a lyophilized stabilizer. Clin Lab 65 (8): 2019 doi: 10.7754/Clin.Lab.2019.190126

Min J, Baoli Y, Trendafilova V, Ketelhut S, Kastl L, Greve B, Kemper B: Quantitative phase imaging of cells in a flow cytometry arrangement utilizing Michelson interferometer-based off-axis digital holographic microscopy. Journal of Biophotonics, 2019 doi: 10.1002/jbio.201900085 (gemeinsame Letztautoren)                                  

Vitale D, Kumar S, Greve B, Jang B, Oh E, Alaniz L, Götte M: Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance. FEBS Journal 2019  doi: 10.1111/febs.14967                        

Elsayad K, Kröger K, Greve B, Moustakis C, assaf C, Stadler R, Lenz G, weishaupt C, Eich HT: Low-dose total skin electron beam therapy: Quality of life improvement and clinical impact of maintenance and adjuvant treatment in patients with mycosis fungoides or Sezary syndrome. Strahlentherapie und Onkologie, doi: 10.1007/s00066-019-01517-7, 2019

Gadalla R, Hassan H, Ibrahim SA, Abdullah MS, Gaballah A, Greve B, El-Deeb S, El-Shinawi M, Mohamed MM: Tumor microenvironmental plasmacytoid dendritic cells contribute to breast cancer lymph node metastasis via CXCR4/SDF-1 axis. Breast Cancer Res Treat 10. doi: 10.1007/s10549-019-05129-8, 2019


Troschel FM, Böhly N, Borrmann K, Braun T, Schwickert A, Kiesel L, Eich HT, Götte M, Greve B: miR-142-3p attenuates breast cancer stem cell characteristics and decreases radioresistance in vitro. Tumor Biology DOI: 10.1177/1010428318791887, 2018


Ibrahim SA, Gadalla R, El-Ghonaimy E, Samir O, Mohamed HT, Hassan H, Greve B, El-Shinawi-M, Mohamed MM, Götte M: Syndecan-1 is a novel molecular marker for triple negative inflammatory breast cancer and modulates the cancer stem cell phenotype via the IL-6/STAT3 and Notch signaling pathways. Molecular Cancer 16 (1): 57, 2017

Min J, Yao B, Ketelhut S, Greve B, Kemper B: Simple and fast spectral domain algorithm for quantitiative phase imaging of living cells with digital holographic microscopy. Optics Letters 42 (2): 227-230, 2017

Viola M, Brüggemann K, Karousou E, Caon I, Carava E, Vigetti D, Greve B, Stock C, De Luca G, Passi A, Götte M: MDA-MB-231 breast cancer cell viability, motility and matrix adhesion are regulated by complex interplay of heparin sulfate, chondroitin-/dermatan sulfate and hyaluronan biosynthesis. Glycoconj J 34: 411-420, 2017

Turko NA, Isbach M, Ketelhut S, Greve B, Schnekenburger J, Shaked NT, Kemper B: Multi-modal and photothermal quantitative phase imaging of living cells with nanoparticles in a combined setup. Proc. of SPIE-OSA 10414, 104140E, 2017


Eggers JC, Martino V, Reinbold R, Schäfer SD, Kiesel L, Starzinski-Powitz A, Schüring AN, Kemper B, Greve B*, Götte M*: microRNA mir-200b affects proliferation, invasiveness and stemness of endometriotic cells by trageting ZEB1, ZEB2 and KLF4. Reproductive BioMedicine Online doi: 10.1016/j.rbmo, 2016 (gemeinsame Letztautoren)

Nemes A, Fortmann T, Poeschke S, Greve B, Prevedollo D, Santacroce A, Stummer W, Senner V, Ewelt C: 5-ALA Fluorescence in Native Pituitary Adenoma Cell Lines: Resection Control and Basis for Photodynamic Therapy (PDT)?. PLosOne 11 (9): e0161364, 2016

Viola M, Brüggemann K, Karousou E, Caon I, Caravá E, Vigetti D, Greve B, Stock C, De Luca G, Passi A, Götte M: MDA-MB-231 breast cancer cell viability, montility and matrix adhesion are regulated by a complex interplay of heparin sulfate, chondroitin-/dermantan sulfate and hyaluronan biosynthesis. Glycoconjugate Journal 2016 DOI 10.1007


Spaniol K, Metzger M, Roth M, Greve B, Mertsch S, Geerling G, Schrader S: Engineering of a secretory active three-dimensional lacrimal gland construct on the basis of decellularized lacrimal gland tissue. Tissue engineering Part A, 2015 E-Pub


Sterzing F, Brunner T, Ernst I, Baus WW, Greve B, Herfarth K, Guckenberger M: Stereotactic Body Radiotherapy (SBRT) for liver tumors: priciple and practical guidelines - by the DEGRO working group "Stereotactic radiotherapy". Strahlentherapie und Onkologie, 2014 E-pup

Bernemann C, Hülsewig C, Ruckert C, Schäfer S, Blümel L, Hempel G, Götte M, Greve B, Barth PJ, Kiesel L, Liedke C: Influence of secreted frizzled receptor protein 1 (SFRP1) on neoadjuvant chemotherapy in triple negative breast cancer doen not rely on WNT signaling. Molecular Cancer 13, 2014


Weidner J, Cassens U, Göhde W, Wüllenweber J, Greve B: A new triplex real time PCR which distinuishing between MRSA, MSSA and mecA coagulase negative strains by means of melting point analysis using SYTO9. Clinical Laboratory 59: 795-804, 2013

Ibrahim S, Hassan H, Vilardo L, Schneider C, Kelsch R, Kiesel L, Eich HT, Reinbold R, Greve B*, Götte M*: Syndecan-1 (CD138) modulates triple negative breast cancer stem cell properties via regulation of IL-6-mediated STAT3 signaling. PlosOne 8 (12), e85737, 2013 ( *shared corresponding authors)

Adammek M*, Greve B*, Kässens N, Schneider C, Brüggemann K, Kampmeyer C, Schüring A, Starzinski-Powitz A, Kiesel L, Götte M,: microRNA miR-145 inhibits proliferation, invasiveness and stem cell phenotype of an in vitro endometriosis model by targeting multiple cytoskeletal elements and pluripotency factors. Fertility and Sterility, 2013 (* gemeinsame Erstautoren) E-pup

Hassan H, Greve B, Pavao MSG, Kiesel L, Ibrahim SA, Götte M: Syndecan-1 modulates beta-integrin-and IL-6-dependent functions in breast cancer cell adhesion, migration and resistance to irradiation. FEBS Journal, 2013 E-pup


Greve B, Sheikh-Mounessi F, Ernst I, Götte M, Eich HT: Survivin, a target to modulate the radiosensitivity of Ewing´s sarcoma. Strahlentherapie und Onkologie, 188 (11): 1038-1047, 2012

Greve B, Bölling T, Amler S, Rössler U, Gomolka M, Mayer C, Popanda O, Dreffke K, Rickinger A, Fritz E, Eckardt-Schupp F, Sauerland M, Braselmann H, Sauter W, Illig T, Riesenbeck D, Könemann S, Willich N, Mörtl S, Eich HT, Schmezer P: Evulation of Different Biomarkers to Predict Individual Radiosensitivity in an Inter-Laboratory Comparison - Lessons for Future Studies. PLoSOne, 7 (10): e47185, 2012

Weidner J, Cassens U, Göhde W, Wüllenweber J, Greve B: A new Real Time PCR which distinguishing between MRSA, MSSA and mecA coagulase negative Strains by means of Melting Point Analysis using SYTO9. Clinical Laboratory 2012 in press

Greve B, Spaniol K, Eich HT, Götte M: Flow cytometry in cancer stem cell analysis and sorting. Cytometry A 81 (4): 284-93, 2012

Schneider C, Kässens N, Greve B, Hassan H, Schüring A, Starzinski-Powitz A, Kiesel L, Seidler D, Götte M: Targeting of Syndecan-1 by microRNAmiR-10b modulates invasiveness of endometriotic cells via dysregulation of the proteolytic milieu and IL-6 secretion. Sterility and Fertility, 2012 in press

Przibilla S, Dartmann S, Vollmer A, Ketelhut S, Greve B, von Bally G, Kemper B: Sensing dynamic cytoplasm refractive index changes of different cells with quantitative phase microscopy using incorporated microspheres as optical probes. Journal of Biomedical Optics 2012 E-pub


Di Marco G, Rustemyer P, Brand M, Koch R, Kentrup D, Grabner A, Greve B, Wittkowski W, Pavenstädt H, Hausberg M, Reuter S, Lang D: Circulating Endothelial Progenitor Cells in Kidney Transplant Patients. PLOS one 6 (9): e24046, 2011 E-pub

Meyer C, Popanda O, Greve B, Fritz E, Illig T, Eckhardt-Schupp F, Gomolka M, Benner A, Schmezer P, A radiation-induced gene expression signature as a tool to predict acute radiotherapy-induced side effects. Cancer Letters, 2011 online

Götte M*, Greve B*, Kelsch R*, Müller-Uthoff H, Weiss K, Masouleh BH, Kiesel L, Buchweitz O:The adult stem cell marker Mushashi-1 modulates endometrial Carcinoma cell cycle progression and apoptosis via Notch-1 and p21WAF1/CIP1. British Journal Cancer 2011 online; *gemeinsame Erstautoren

Weidner J, Cassens U, Göhde W, Sibrowsky W, Odaibo G, Olaleye D, Reichelt D, Greve B: A world wide applicable Flow Cytometry based method for the detection of HIV-1 proviral DNA. Journal of Virological Methods 2011 online


Bölling T, Kolkmeyer A, Greve B, Ernst I, Willich N, Könemann S, Heterogeneity of radiation- and TNF-alpha-induced programmed cell death in carcinoma, sarcoma and lymphoma cell lines. Anticancer Research 30 (7): 2857-61, 2010

Wesbur S, Lanvers-Karminsky C, Duran-Seuberth I, Bölling T, Schäfer KL, Braun Y, Willich N, Greve B: Association of telomerase activity with radio- and chemosensitivity in neuroblastomas. Radiation Oncology 5 (1): 66, 2010

Agelopoulos K, Greve B, Schmidt H, Pospisil H, Kurtz, S, Bartkowiak K, Andreas, A, Wieczorek M, Korsching E, Buerger H, Brandt B: Selective regain of egfr gene copies in CD44+/CD24-/low breast cancer cellular model MDA-MB-468. BMC Cancer 10, online , 2010


Greve B, Weidner J, Cassens U, Odaibo G, Olaleye D, Sibrowski W, Reichelt D, Nasdala I, Göhde W: A New affordable Flow Cytometry Based Method to Measure HIV-1 Viral Load.
Cytometry Part A, 75 (3): 199-206, 2009

Greve B, Dreffke K, Rickinger A, Könemann S, Fritz E, Eckardt-Schupp F, Amler S, Sauerland C, Braselmann H, Sauter W, Illig T, Schmezer P, Gomolka M, Willich N, Bölling T: Multicentric investigation of ionising radiation-induced cell death as a predictive parameter of individual radiosensitivity. Apoptosis, 14 (2): 226-235, 2009


Rustemeyer P, Greve B, Stehling M, Wittkowski W: Flow Cytometric Identification, Enumeration, Purification and Expension of CD133+ and VEGF-R2+ Endothelial Progenitor Cells from Peripheral Blood. Journal of Immunoassay and Immunochemistry, 28 (1): 13-23, 2007


Greve B, Beller C, Cassens U, Sibrowski W, Göhde, W: The impact of erythrocyte lysing procedures on the recovery of hematopoietic progenitor cells in flow cytometric analysis. Stem Cells, 24 (3): 793-799, 2006


Severin E*, Greve B*, Pascher E, Wedemeyer N, Hacker-Klom U, Silling G, Kienast J, Willich N, Göhde W: Evidence for predictive validity of blood assays to evaluate individual radiosensitivity. International Journal of Radiation Oncology Biology Physics 64 (1): 242-250, online published 2005 (* gemeinsame Erstautoren)


Leiter Strahlenbiologie

Prof. Dr. rer. nat. Burkhard Greve