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Klinik für Neurochirurgie

Publikationen

2021

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2020

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2019

The Use of 5-Aminolevulinic Acid in Low-Grade Glioma Resection: A Systematic Review.

Almekkawi AK, El Ahmadieh TY, Wu EM, Abi-Aad KR, Aoun SG, Plitt AR, El Tecle NE, Patel T, Stummer W, Bendok BR.

Oper Neurosurg (Hagerstown). 2019 Dec 12. pii: opz336. doi: 10.1093/ons/opz336. [Epub ahead of print]

Review of clinical trials in intraoperative molecular imaging during cancer surgery.

Lee JYK, Cho SS, Stummer W, Tanyi JL, Vahrmeijer AL, Rosenthal E, Smith B, Henderson E, Roberts DW, Lee A, Hadjipanayis CG, Bruce JN, Newman JG, Singhal S.

J Biomed Opt. 2019 Dec;24(12):1-8. doi: 10.1117/1.JBO.24.12.120901.

The rise of quality indicators in neurosurgery: 30-day unplanned reoperation rate evaluated in 3760 patients-a single-center experience.

Suero Molina E, Schildmacher C, Doods J, Freistühler M, Hellwig SJ, Stummer W, Schipmann S.

Acta Neurochir (Wien). 2020 Jan;162(1):147-156. doi: 10.1007/s00701-019-04146-2. Epub 2019 Dec 4.

EANO-EURACAN clinical practice guideline for diagnosis, treatment, and follow-up of post-pubertal and adult patients with medulloblastoma.

Franceschi E, Hofer S, Brandes AA, Frappaz D, Kortmann RD, Bromberg J, Dangouloff-Ros V, Boddaert N, Hattingen E, Wiestler B, Clifford SC, Figarella-Branger D, Giangaspero F, Haberler C, Pietsch T, Pajtler KW, Pfister SM, Guzman R, Stummer W, Combs SE, Seidel C, Beier D, McCabe MG, Grotzer M, Laigle-Donadey F, Stücklin ASG, Idbaih A, Preusser M, van den Bent M, Weller M, Hau P.

Lancet Oncol. 2019 Dec;20(12):e715-e728. doi: 10.1016/S1470-2045(19)30669-2. Review.

Letter: Parasagittal/Falcine Tumor Location Strongly Predicts Human Telomerase Reverse Transcriptase Promoter Mutations in High-Grade Meningiomas.

Peetz-Dienhart S, Spille DC, Sporns PB, Adeli A, Bunk EC, Wagner A, Paulus W, Stummer W, Hess K, Brokinkel B.

Neurosurgery. 2019 Dec 3. pii: nyz474. doi: 10.1093/neuros/nyz474. [Epub ahead of print] No abstract available.

Ependymal fluorescence in fluorescence-guided resection of malignant glioma: a systematic review.

Müther M, Stummer W.

Acta Neurochir (Wien). 2019 Nov 21. doi: 10.1007/s00701-019-04144-4. [Epub ahead of print] Review.

High-Intensity Physical Exercise in a Glioblastoma Patient under Multimodal Treatment.

Troschel FM, Brandt R, Wiewrodt R, Stummer W, Wiewrodt D.

Med Sci Sports Exerc. 2019 Dec;51(12):2429-2433. doi: 10.1249/MSS.0000000000002067.

Human CCR5high effector memory cells perform CNS parenchymal immune surveillance via GZMK-mediated transendothelial diapedesis.

Herich S, Schneider-Hohendorf T, Rohlmann A, Khaleghi Ghadiri M, Schulte-Mecklenbeck A, Zondler L, Janoschka C, Ostkamp P, Richter J, Breuer J, Dimitrov S, Rammensee HG, Grauer OM, Klotz L, Gross CC, Stummer W, Missler M, Zarbock A, Vestweber D, Wiendl H, Schwab N.

Brain. 2019 Nov 1;142(11):3411-3427. doi: 10.1093/brain/awz301.

Health-related quality of life and neurocognitive functioning with lomustine-temozolomide versus temozolomide in patients with newly diagnosed, MGMT-methylated glioblastoma (CeTeG/NOA-09): a randomised, multicentre, open-label, phase 3 trial.

Weller J, Tzaridis T, Mack F, Steinbach JP, Schlegel U, Hau P, Krex D, Grauer O, Goldbrunner R, Bähr O, Uhl M, Seidel C, Tabatabai G, Brehmer S, Bullinger L, Galldiks N, Schaub C, Kebir S, Stummer W, Simon M, Fimmers R, Coch C, Glas M, Herrlinger U, Schäfer N.

Lancet Oncol. 2019 Oct;20(10):1444-1453. doi: 10.1016/S1470-2045(19)30502-9. Epub 2019 Sep 2.

Markers for Identifying and Targeting Glioblastoma Cells during Surgery.

Schipmann S, Schwake M, Suero Molina E, Stummer W.

J Neurol Surg A Cent Eur Neurosurg. 2019 Nov;80(6):475-487. doi: 10.1055/s-0039-1692976. Epub 2019 Aug 29.

Spectroscopic measurement of 5-ALA-induced intracellular protoporphyrin IX in pediatric brain tumors.

Schwake M, Kaneko S, Suero Molina E, Müther M, Schipmann S, Köchling M, Brentrup A, Stummer W.

Acta Neurochir (Wien). 2019 Oct;161(10):2099-2105. doi: 10.1007/s00701-019-04039-4. Epub 2019 Aug 21.

Intraoperative fluorescence diagnosis in the brain: a systematic review and suggestions for future standards on reporting diagnostic accuracy and clinical utility.

Stummer W, Koch R, Valle RD, Roberts DW, Sanai N, Kalkanis S, Hadjipanayis CG, Suero Molina E.

Acta Neurochir (Wien). 2019 Oct;161(10):2083-2098. doi: 10.1007/s00701-019-04007-y. Epub 2019 Jul 30. Review.

Supramarginal resection of glioblastoma: 5-ALA fluorescence, combined intraoperative strategies and correlation with survival.

Certo F, Stummer W, Farah JO, Freyschlag C, Visocchi M, Morrone A, Altieri R, Toccaceli G, Peschillo S, Thomè C, Jenkinson M, Barbagallo G.

J Neurosurg Sci. 2019 Jul 29. doi: 10.23736/S0390-5616.19.04787-8. [Epub ahead of print]

5-Aminolevulinic Acid Fluorescence-Guided Resection of 18F-FET-PET Positive Tumor Beyond Gadolinium Enhancing Tumor Improves Survival in Glioblastoma.

Müther M, Koch R, Weckesser M, Sporns P, Schwindt W, Stummer W.

Neurosurgery. 2019 Dec 1;85(6):E1020-E1029. doi: 10.1093/neuros/nyz199.

Brain invasion in meningiomas: does surgical sampling impact specimen characteristics and histology?

Timme M, Thomas C, Spille DC, Stummer W, Ebel H, Ewelt C, Hans FJ, Schick U, Puchner M, Wildförster U, Bruns B, Trost HA, Holling M, Grauer O, Hess K, Brokinkel B.

Neurosurg Rev. 2019 Jun 3. doi: 10.1007/s10143-019-01125-0.

Clinical, radiological, and histopathological predictors for long-term prognosis after surgery for atypical meningiomas.

Streckert EMS, Hess K, Sporns PB, Adeli A, Brokinkel C, Kriz J, Holling M, Eich HT, Paulus W, Spille DC, van Eck ATCJ, Raleigh DR, McDermott MW, Stummer W, Brokinkel B.

Acta Neurochir (Wien). 2019 May 31. doi: 10.1007/s00701-019-03956-8.

Prediction of high-grade histology and recurrence in meningiomas using routine preoperative magnetic resonance imaging - A systematic review.

Spille DC, Sporns PB, Heß K, Stummer W, Brokinkel B.

World Neurosurg. 2019 May 10. pii: S1878-8750(19)31291-4. doi: 10.1016/j.wneu.2019.05.017.

Clinical vasospasm after an extended endoscopic assisted approach for recurrent pituitary adenoma. Illustrative case and systematic review of the literature.

Suero Molina E, Di Somma A, Stummer W, Briganti F, Cavallo LM.

World Neurosurg. 2019 Apr 16. pii: S1878-8750(19)31038-1. doi: 10.1016/j.wneu.2019.04.046. [Epub ahead of print] Review.

Effect of Postoperative Radiotherapy for Brain Metastases: An Analysis.

Oertel M, Baehr A, Habibeh O, Haverkamp U, Stummer W, Eich HT, Trog D.

Oncol Res Treat. 2019 Apr 17;42(5):253-259. doi: 10.1159/000499323. [Epub ahead of print]

5-ALA fluorescence-guided surgery in pediatric brain tumors-a systematic review.

Schwake M, Schipmann S, Müther M, Köchling M, Brentrup A, Stummer W.

Acta Neurochir (Wien). 2019 Apr 13. doi: 10.1007/s00701-019-03898-1. [Epub ahead of print] Review.

Intracavitary radioimmunotherapy of high-grade gliomas: present status and future developments.

Reulen HJ, Suero Molina E, Zeidler R, Gildehaus FJ, Böning G, Gosewisch A, Stummer W.

Acta Neurochir (Wien). 2019 Apr 12. doi: 10.1007/s00701-019-03882-9. [Epub ahead of print] Review.

Telomerase activity, TERT expression, hTERT promoter alterations, and alternative lengthening of the telomeres (ALT) in meningiomas - a systematic review.

Stögbauer L, Stummer W, Senner V, Brokinkel B.

Neurosurg Rev. 2019 Feb 20. doi: 10.1007/s10143-019-01087-3. [Epub ahead of print] Review.

Lomustine-temozolomide combination therapy versus standard temozolomide therapy in patients with newly diagnosed glioblastoma with methylated MGMT promoter (CeTeG/NOA-09): a randomised, open-label, phase 3 trial.

Herrlinger U, Tzaridis T, Mack F, Steinbach JP, Schlegel U, Sabel M, Hau P, Kortmann RD, Krex D, Grauer O, Goldbrunner R, Schnell O, Bähr O, Uhl M, Seidel C, Tabatabai G, Kowalski T, Ringel F, Schmidt-Graf F, Suchorska B, Brehmer S, Weyerbrock A, Renovanz M, Bullinger L, Galldiks N, Vajkoczy P, Misch M, Vatter H, Stuplich M, Schäfer N, Kebir S, Weller J, Schaub C, Stummer W, Tonn JC, Simon M, Keil VC, Nelles M, Urbach H, Coenen M, Wick W, Weller M, Fimmers R, Schmid M, Hattingen E, Pietsch T, Coch C, Glas M; Neurooncology Working Group of the German Cancer Society.

Lancet. 2019 Feb 16;393(10172):678-688. doi: 10.1016/S0140-6736(18)31791-4. Epub 2019 Feb 14.

5-ALA fluorescence-guided surgery of CNS tumors.

Hadjipanayis CG, Stummer W, Sheehan JP.

J Neurooncol. 2019 Feb;141(3):477-478. doi: 10.1007/s11060-019-03109-y. No abstract available.

5-ALA and FDA approval for glioma surgery.

Hadjipanayis CG, Stummer W.

J Neurooncol. 2019 Feb;141(3):479-486. doi: 10.1007/s11060-019-03098-y. Epub 2019 Jan 14. Review.

Adverse events in brain tumor surgery: incidence, type, and impact on current quality metrics.

Schipmann S, Brix T, Varghese J, Warneke N, Schwake M, Brokinkel B, Ewelt C, Dugas M, Stummer W.

Acta Neurochir (Wien). 2019 Feb;161(2):287-306. doi: 10.1007/s00701-018-03790-4. Epub 2019 Jan 11.

Light can treat inoperable brain tumours.

Stepp H, Stummer W.

Nature. 2019 Jan;565(7738):161. doi: 10.1038/d41586-019-00020-4. No abstract available.

Second-look strokectomy of cerebral infarction areas in patients with severe herniation.

Schwake M, Schipmann S, Müther M, Stögbauer L, Hanning U, Sporns PB, Ewelt C, Dziewas R, Minnerup J, Holling M, Stummer W.

J Neurosurg. 2019 Jan 4:1-9. doi: 10.3171/2018.8.JNS18692. [Epub ahead of print]

Established and emerging uses of 5-ALA in the brain: an overview.

Díez Valle R, Hadjipanayis CG, Stummer W.

J Neurooncol. 2019 Feb;141(3):487-494. doi: 10.1007/s11060-018-03087-7. Epub 2019 Jan 3.

Cell injury and receptor expression in the epileptic human amygdala.

Jafarian M, Modarres Mousavi SM, Alipour F, Aligholi H, Noorbakhsh F, Ghadipasha M, Gharehdaghi J, Kellinghaus C, Kovac S, Khaleghi Ghadiri M, Meuth SG, Speckmann EJ, Stummer W, Gorji A.

Neurobiol Dis. 2019 Apr;124:416-427. doi: 10.1016/j.nbd.2018.12.017. Epub 2018 Dec 24.

Prediction of brain invasion in patients with meningiomas using preoperative magnetic resonance imaging.

Adeli A, Hess K, Mawrin C, Streckert EMS, Stummer W, Paulus W, Kemmling A, Holling M, Heindel W, Schmidt R, Spille DC, Sporns PB, Brokinkel B.

Oncotarget. 2018 Nov 13;9(89):35974-35982. doi: 10.18632/oncotarget.26313. eCollection 2018 Nov 13.

Combined intracavitary thermotherapy with iron oxide nanoparticles and radiotherapy as local treatment modality in recurrent glioblastoma patients.

Grauer O, Jaber M, Hess K, Weckesser M, Schwindt W, Maring S, Wölfer J, Stummer W.

J Neurooncol. 2019 Jan;141(1):83-94. doi: 10.1007/s11060-018-03005-x. Epub 2018 Dec 1.

PMID:

Surgical Adjuncts to Increase the Extent of Resection: Intraoperative MRI, Fluorescence, and Raman Histology.

Hollon T, Stummer W, Orringer D, Suero Molina E.

Neurosurg Clin N Am. 2019 Jan;30(1):65-74. doi: 10.1016/j.nec.2018.08.012. Review.

Local Tumor Control and Clinical Symptoms After Gamma Knife Radiosurgery for Residual and Recurrent Vestibular Schwannomas.

Suero Molina E, van Eck ATCJ, Sauerland C, Schipmann S, Horstmann G, Stummer W, Brokinkel B.

World Neurosurg. 2019 Feb;122:e1240-e1246. doi: 10.1016/j.wneu.2018.11.022. Epub 2018 Nov 14.

Fluorescence-guided surgery with aminolevulinic acid for low-grade gliomas.

Hendricks BK, Sanai N, Stummer W.

J Neurooncol. 2019 Jan;141(1):13-18. doi: 10.1007/s11060-018-03026-6. Epub 2018 Oct 26. Review.

2018

Complementary Molecular and Elemental Mass-Spectrometric Imaging of Human Brain Tumors Resected by Fluorescence-Guided Surgery.

Kröger S, Niehoff AC, Jeibmann A, Sperling M, Paulus W, Stummer W, Karst U.

Anal Chem. 2018 Oct 16;90(20):12253-12260. doi: 10.1021/acs.analchem.8b03516. Epub 2018 Oct 2.

Impact of distress screening algorithm for psycho-oncological needs in neurosurgical patients.

Rapp M, Schipmann S, Hoffmann K, Wiewrodt R, Steiger HJ, Kamp M, Stummer W, Wiewrodt D, Sabel M.

Oncotarget. 2018 Aug 3;9(60):31650-31663. doi: 10.18632/oncotarget.25833. eCollection 2018 Aug 3.

Spinal meningiomas - Risks and potential of an increasing age at the time of surgery.

Schwake M, Adeli A, Sporns P, Ewelt C, Schmitz T, Sicking J, Hess K, Cäcilia Spille D, Paulus W, Stummer W, Brokinkel B.

J Clin Neurosci. 2018 Nov;57:86-92. doi: 10.1016/j.jocn.2018.08.030. Epub 2018 Aug 23.

Is Visible Aminolevulinic Acid-Induced Fluorescence an Independent Biomarker for Prognosis in Histologically Confirmed (World Health Organization 2016) Low-Grade Gliomas?

Jaber M, Ewelt C, Wölfer J, Brokinkel B, Thomas C, Hasselblatt M, Grauer O, Stummer W.

Neurosurgery. 2018 Aug 9. doi: 10.1093/neuros/nyy365. [Epub ahead of print]

Letter to the Editor. Brain invasion and the risk for postoperative hemorrhage and neurological deterioration after meningioma surgery.

Brokinkel B, Sicking J, Spille DC, Hess K, Paulus W, Stummer W.

J Neurosurg. 2018 Sep;129(3):849-851. doi: 10.3171/2018.5.JNS181287. Epub 2018 Aug 10. No abstract available.

Is the Simpson Grading System Applicable to Estimate the Risk of Tumor Progression After Microsurgery for Recurrent Intracranial Meningioma?

Schipmann S, Schwake M, Sporns PB, Voß KM, Sicking J, Spille DC, Hess K, Paulus W, Stummer W, Brokinkel B.

World Neurosurg. 2018 Nov;119:e589-e597. doi: 10.1016/j.wneu.2018.07.215. Epub 2018 Aug 4.

FGFR1:TACC1 fusion is a frequent event in molecularly defined extraventricular neurocytoma.

Sievers P, Stichel D, Schrimpf D, Sahm F, Koelsche C, Reuss DE, Wefers AK, Reinhardt A, Huang K, Ebrahimi A, Hou Y, Pajtler KW, Pfister SM, Hasselblatt M, Stummer W, Schick U, Hartmann C, Hagel C, Staszewski O, Reifenberger G, Beschorner R, Coras R, Keyvani K, Kohlhof P, Diomedi-Camassei F, Herold-Mende C, Giangaspero F, Rushing E, Giannini C, Korshunov A, Jones DTW, von Deimling A.

Acta Neuropathol. 2018 Aug;136(2):293-302. doi: 10.1007/s00401-018-1882-3. Epub 2018 Jul 5.

The evolution of cranial meningioma surgery-a single-center 25-year experience.

Sicking J, Voß KM, Spille DC, Schipmann S, Holling M, Paulus W, Hess K, Steinbicker AU, Stummer W, Grauer O, Wölfer J, Brokinkel B.

Acta Neurochir (Wien). 2018 Sep;160(9):1801-1812. doi: 10.1007/s00701-018-3617-6. Epub 2018 Jul 5.

5-ALA in the management of malignant glioma.

Stepp H, Stummer W.

Lasers Surg Med. 2018 Jul;50(5):399-419. doi: 10.1002/lsm.22933. Epub 2018 May 8. Review.

Brain invasion and the risk of seizures in patients with meningioma.

Hess K, Spille DC, Adeli A, Sporns PB, Brokinkel C, Grauer O, Mawrin C, Stummer W, Paulus W, Brokinkel B.

J Neurosurg. 2018 Apr 1:1-8. doi: 10.3171/2017.11.JNS172265. [Epub ahead of print]

Human Neural Stem/Progenitor Cells Derived From Epileptic Human Brain in a Self-Assembling Peptide Nanoscaffold Improve Traumatic Brain Injury in Rats.

Jahanbazi Jahan-Abad A, Sahab Negah S, Hosseini Ravandi H, Ghasemi S, Borhani-Haghighi M, Stummer W, Gorji A, Khaleghi Ghadiri M.

Mol Neurobiol. 2018 Dec;55(12):9122-9138. doi: 10.1007/s12035-018-1050-8. Epub 2018 Apr 12.

In-Vitro Use of 5-ALA for Photodynamic Therapy in Pediatric Brain Tumors.

Schwake M, Nemes A, Dondrop J, Schroeteler J, Schipmann S, Senner V, Stummer W, Ewelt C.

Neurosurgery. 2018 Dec 1;83(6):1328-1337. doi: 10.1093/neuros/nyy054.

Visualizing protoporphyrin IX formation in the dura tail of meningiomas by mass spectrometry imaging.

Brokinkel B, Kröger S, Senner V, Jeibmann A, Karst U, Stummer W.

Acta Neurochir (Wien). 2018 Jul;160(7):1433-1437. doi: 10.1007/s00701-018-3488-x. Epub 2018 Feb 15.

Diffuse Astrocytoma, IDH-Wildtype: A Dissolving Diagnosis.

Hasselblatt M, Jaber M, Reuss D, Grauer O, Bibo A, Terwey S, Schick U, Ebel H, Niederstadt T, Stummer W, von Deimling A, Paulus W.

J Neuropathol Exp Neurol. 2018 Jun 1;77(6):422-425. doi: 10.1093/jnen/nly012.

The difficulty of predicting clinical outcome after intended submaximal resection of large vestibular Schwannomas.

MacKenzie R, Sporns P, Zoubi T, Koopmann M, Ewelt C, Stummer W, Brokinkel B, Suero Molina E.

J Clin Neurosci. 2018 Apr;50:62-68. doi: 10.1016/j.jocn.2018.01.033. Epub 2018 Feb 21.

Conscious sedation with dexmedetomidine compared with asleep-awake-asleep craniotomies in glioma surgery: an analysis of 180 patients.

Suero Molina E, Schipmann S, Mueller I, Wölfer J, Ewelt C, Maas M, Brokinkel B, Stummer W.

J Neurosurg. 2018 Nov 1;129(5):1223-1230. doi: 10.3171/2017.7.JNS171312.

Where and When to Cut? Fluorescein Guidance for Brain Stem and Spinal Cord Tumor Surgery-Technical Note.

Suero Molina E, Stummer W.

Oper Neurosurg (Hagerstown). 2018 Sep 1;15(3):325-331. doi: 10.1093/ons/opx269.

Simpson grade IV resections of skull base meningiomas: does the postoperative tumor volume impact progression?

Brokinkel B, Stummer W, Sporns P.

J Neurooncol. 2018 Mar;137(1):219-221. doi: 10.1007/s11060-017-2715-2. Epub 2017 Dec 14. No abstract available.

Shifting cancer care towards Multidisciplinarity: the cancer center certification program of the German cancer society.

Kowalski C, Graeven U, von Kalle C, Lang H, Beckmann MW, Blohmer JU, Burchardt M, Ehrenfeld M, Fichtner J, Grabbe S, Hoffmann H, Iro H, Post S, Scharl A, Schlegel U, Seufferlein T, Stummer W, Ukena D, Ferencz J, Wesselmann S.

BMC Cancer. 2017 Dec 14;17(1):850. doi: 10.1186/s12885-017-3824-1.

[Neurointensive care medicine-from where, where to?]

Stummer W, Schwab S, Fink GR.

Nervenarzt. 2018 Feb;89(2):144-146. doi: 10.1007/s00115-017-0457-1. German. No abstract available.

Initial psycho-oncological counselling in neuro-oncology: analysis of topics and needs of brain tumour patients.

Schipmann S, Suero Molina E, Frasch A, Stummer W, Wiewrodt D.

J Neurooncol. 2018 Feb;136(3):505-514. doi: 10.1007/s11060-017-2670-y. Epub 2017 Nov 17.

Quality of life in the GLARIUS trial randomizing bevacizumab/irinotecan versus temozolomide in newly diagnosed, MGMT-nonmethylated glioblastoma.

Schäfer N, Proescholdt M, Steinbach JP, Weyerbrock A, Hau P, Grauer O, Goldbrunner R, Friedrich F, Rohde V, Ringel F, Schlegel U, Sabel M, Ronellenfitsch MW, Uhl M, Grau S, Hänel M, Schnell O, Krex D, Vajkoczy P, Tabatabai G, Mack F, Schaub C, Tzaridis T, Nießen M, Kebir S, Leutgeb B, Urbach H, Belka C, Stummer W, Glas M, Herrlinger U.

Neuro Oncol. 2018 Jun 18;20(7):975-985. doi: 10.1093/neuonc/nox204.

Multicenter pilot study of radiochemotherapy as first-line treatment for adults with medulloblastoma (NOA-07).

Beier D, Proescholdt M, Reinert C, Pietsch T, Jones DTW, Pfister SM, Hattingen E, Seidel C, Dirven L, Luerding R, Reijneveld J, Warmuth-Metz M, Bonsanto M, Bremer M, Combs SE, Rieken S, Herrlinger U, Kuntze H, Mayer-Steinacker R, Moskopp D, Schneider T, Beringer A, Schlegel U, Stummer W, Welker H, Weyerbrock A, Paulsen F, Rutkowski S, Weller M, Wick W, Kortmann RD, Bogdahn U, Hau P.

Neuro Oncol. 2018 Feb 19;20(3):400-410. doi: 10.1093/neuonc/nox155.

Gadolinium-based contrast agents induce Gadolinium deposits in cerebral vessel walls, while the neurophil is not affected: an autopsy study.
Acta Neuropahtol 2018 Jul:136(1):127-138
Fingerhut S, Sperling M, Holling M, Niederstadt T, Allkemper T, Radbruch A, Heindel W, Paulus W, Jeibmann A, Karst U.

5-ALA in the management of malignant glioma
Lasers Surg Med 2018 Jul:50(5):299-419
Stepp H, Stummer W.

Brain Invasion and the risk of seizures in patients with with meningeoma
J Neurosurg 2018 Apr 27:1-8
Hess K, Spille DC, Adeli A, Sporns PB, Brokinkel C, Grauer O, Mawrin C, Stummer W, Paulus W, Brokinkel B.

Human Neural Stem/Progenitor Cells Derived From Epileptic Human Brain in a Self-Assembling Peptide Nanoscaffold Improve Traumatic Brain Injury in Rats
Mol Neurobiol 2018 Apr12
Jahanbazi Jahan Abad A, Sahab Negah S, Hosseini Ravandi H, Ghasemi S, Borhani-Haghighi M, Stummer W, Gorji A, Khaleghi Ghadiri M.

In-Vitro Use of 5-ALA for Photodynamic Therapy in Pediatric Brain Tumors
Neurosurgery 2018 Mar 12.
Schwake M, Nemes A, Dondrop J, Schroeteler J, Schipmann S, Senner V, Stummer W, Ewelt C.

Visualizing protoporphyrin IX Formation in the dura tail of meningiomas by mass spectrometry Imaging
Acta Neurochir (Wien) 2018 Jul:160(7):1433-1437
Brokinkel B, Kröger S, Senner V, Jeibmann A, Karst U, Stummer W.

Diffuse Astrocytoma, IDH-Wildtype: A Dissolving Diagnosis
J Neuropathol Exp Neurol 2018 Jun 1:77(6):422-425
Hasselblatt M, Jaber M, Reuss D, Grauer O, Bibo A, Terwey S, Schick U, Ebel H, Niederstadt T, Stummer W, von Deimling A, Paulus W.

The difficulty of predicting clinical outcome after intended submaximal resection of large vestibular Schwannomas. J Clin Neurosci 2018 Apr 50:62-68
MacKenzie R, Sporns P, Zoubi T, Koomann M, Ewelt C, Stummer W, Brokinkel B, Suero Moina E.

Spatially resolved quantification of gadolinium deposited in the brain of a Patient treated with Gadolinium-based contrast agents.
J Trace Elem Med Biol 2018 Jan:45:125-130
Fingerhut S, Niehoff AC, Sperling M, Jeibmann A, Paulus W, Niederstadt T, Allkemper T, Heindel W, Holling M, Karst U.

Conscious sedation with dexmedetomidine compared with asleep-awake-asleep craniotomies in glioma surgery: an analysis of 180 patients. J Neurosurg. 2018 Jan 12:1-8. doi:
10.3171/2017.7.JNS171312. [Epub ahead of print]
Suero Molina E, Schipmann S, Mueller I, Wölfer J, Ewelt C, Maas M, Brokinkel B, Stummer W.

2017

Initial psycho-oncological counselling in neuro-oncology: analysis of topics and needs of brain tumour patients. J Neurooncol. 2017 Nov 17. doi: 10.1007/s11060-017-2670-y. [Epub ahead of print]
Schipmann S, Suero Molina E, Frasch A, Stummer W, Wiewrodt D.

Where and When to Cut? Fluorescein Guidance for Brain Stem and Spinal Cord Tumor Surgery-Technical Note. Oper Neurosurg (Hagerstown). 2017 Dec 29. doi: 10.1093/ons/opx269. [Epub ahead of print]
Suero Molina E, Stummer W.

Quality of life in the GLARIUS trial randomizing bevacizumab/irinotecan versus temozolomide in newly diagnosed, MGMT-nonmethylated glioblastoma. Neuro Oncol. 2017 Nov 7. doi:10.1093/neuonc/nox204. [Epub ahead of print]
Schäfer N, Proescholdt M, Steinbach JP, Weyerbrock A, Hau P, Grauer O, Goldbrunner R, Friedrich F, Rohde V, Ringel F, Schlegel U, Sabel M, Ronellenfitsch MW, Uhl M, Grau S, Hänel M, Schnell O, Krex D, Vajkoczy P, Tabatabai G, Mack F, Schaub C, Tzaridis T, Nießen M, Kebir S, Leutgeb B, Urbach H, Belka C, Stummer W, Glas M, Herrlinger U. Multicenter pilot study of radio-chemotherapy as first-line treatment for adults with medulloblastoma (NOA-07). Neuro Oncol. 2017 Aug 21. doi:10.1093/neuonc/nox155. [Epub ahead of print]
Dagmar D, Proescholdt M, Reinert C, Pietsch T, Jones DTW, Pfister SM, Hattingen E, Seidel C, Dirven L, Luerding R, Reijneveld J, Warmuth-Metz M, Bonsanto M, Bremer M, Combs S, Rieken S, Herrlinger U, Kuntze H, Mayer-Steinacker R, Moskopp D, Schneider T, Beringer A, Schlegel U, Stummer W, Welker H,
Weyerbrock A, Paulsen F, Rutkowski S, Weller M, Wick W, Kortmann RD, Bogdahn U, Hau P. Maximizing safe resections: the roles of 5-aminolevulinic acid and intraoperative MR imaging in glioma surgery-review of the literature. Neurosurg Rev. 2017 Sep 18. doi: 10.1007/s10143-017-0907-z.
[Epub ahead of print] Review.
Suero Molina E, Schipmann S, Stummer W. Regression of Pineal Lesions: Spontaneous or Iatrogenic? A Case Report and Systematic Literature Review. World Neurosurg. 2017 Aug 24. pii:S1878-8750(17)31407-9. doi:10.1016/j.wneu.2017.08.106. [Epub ahead of print] Review.
Schipmann S, Keurhorst D, Köchling M, Schwake M, Heß K, Sundermann B, Stummer W, Brentrup A. Fluorescence Imaging/Agents in Tumor Resection. Neurosurg Clin N Am. 2017 Oct;28(4):569-583. doi: 10.1016/j.nec.2017.05.009. Epub 2017 Aug 18.
Stummer W, Suero Molina E. Multimodal Imaging of Patients With Gliomas Confirms (11)C-MET PET as a Complementary Marker to MRI for Noninvasive Tumor Grading and Intraindividual Follow-Up After Therapy. Mol Imaging. 2017 Jan 1;16:1536012116687651. doi:10.1177/1536012116687651.
Laukamp KR, Lindemann F, Weckesser M, Hesselmann V, Ligges S, Wölfer J, Jeibmann A, Zinnhardt B, Viel T, Schäfers M, Paulus W, Stummer W, Schober O, Jacobs AH. Illumination in Spinal Surgery Depending on Different Approaches and Light Sources. World Neurosurg. 2017 Sep;105:585-590. doi: 10.1016/j.wneu.2017.06.013. Epub 2017 Jun 9.
Wilbers E, Ewelt C, Schipmann S, Stummer W, Klingenhöfer M. Infrared Thermography in Surgery of Newly Diagnosed Glioblastoma Multiforme: A Technical Case Report. Case Rep Oncol. 2017 Apr 18;10(1):350-355. doi: 10.1159/000470832.
Naydenov E, Minkin K, Penkov M, Nachev S, Stummer W. The Simpson grading in meningioma surgery: does the tumor location influence the prognostic value? J Neurooncol. 2017 Jul;133(3):641-651. doi: 10.1007/s11060-017-2481-1. Epub 2017 May 19.
Voß KM, Spille DC, Sauerland C, Suero Molina E, Brokinkel C, Paulus W, Stummer W, Holling M, Jeibmann A, Brokinkel B. Maximizing safe resections: the roles of 5-aminolevulinic acid and intraoperative MR imaging in glioma surgery-review of the literature.
Neurosurg Rev. 2017 Sep 18.
Suero Molina E, Schipmann S, Stummer W.
Fluorescence Imaging/Agents in Tumor Resection.
Neurosurg Clin N Am. 2017 Oct;28(4):569-583. doi: 10.1016/j.nec.2017.05.009. Epub 2017 Aug 18.
Stummer W, Suero Molina E. Letter: Brain Invasion in Meningiomas-Sex-Associated Differences are not Related to Estrogen-
and Progesterone Receptor Expression.
Neurosurgery. 2017 Apr 5.
Heß K, Spille DC, Wagner A, Stummer W, Paulus W, Brokinkel B. Randomized, Prospective Double-Blinded Study Comparing 3 Different Doses of 5-Aminolevulinic Acid for
Fluorescence-Guided Resections of Malignant Gliomas. Neurosurgery. 2017
Stummer W, Stepp H, Wiestler OD, Pichlmeier U. Endoscopic management of a low-grade thalamic glioma: a safe alternative to open microsurgery? Acta Neurochir (Wien). 2017 Feb 24.
Brokinkel B, Yavuz M, Warneke N, Brentrup A, Hess K, Bleimüller C, Wölfer J,
Stummer W. Intra-operative tissue diagnosis: isn't it time for some reporting guidelines?
Acta Neurochir (Wien). 2017 Feb;159(2):369-370.
Stummer W. Dual-labeling with 5-aminolevulinic acid and fluorescein for fluorescence-guided resection of high-grade gliomas: technical note.
J Neursurgery, 2017 Mar 24
Suero Molina E, Wölfer J, Ewelt C, Ehrhardt A, Brokinkel B, Stummer W.

2016

Computed Tomographic Blend Sign Is associated With Computed Tomographic Angiography Spot Sign and Predicts Secondary Neurological Deterioration After Intracerebral Hemorrhage.
Stroke. 2016 Nov 22
Sporns PB, Schwake M, Schmidt R, Kemmling A, Minnerup J, Schwindt W, Cnyrim C, Zoubi T, Heindel W, Niederstadt T, Hanning U.
5-ALA Fluorescence in Native Pituitary Adenoma Cell Lines: Resection Control and Basis for Photodynamic Therapy (PDT)?
PLoS One. 2016 Sep 1;11(9)
Nemes A, Fortmann T, Poeschke S, Greve B, Prevedello D, Santacroce A, Stummer W, Senner V, Ewelt C. When the infection hits the wound - Matched case-control study in a neurosurgical patient collective including systematic literature review and risk factors analysis.
World Neurosurg. 2016 Aug 6.
Schipmann S, Akalin E, Doods J, Ewelt C, Stummer W, Suero EJ. hTERT promoter methylation in meningiomas and central nervous hemangiopericytomas.
J Neurooncol. 2016 Jul 27.
Fürtjes G, Köchling M, Peetz-Dienhart S, Wagner A, Heß K, Hasselblatt M, Senner V, Stummer W, Paulus W, Brokinkel B. Surgery for meningioma in the elderly and long-term survival: comparison with an age- and sex-matched general population and with younger patients.
J Neurosurg. 2016 Jun 3:1-11.
Brokinkel B, Holling M, Spille DC, Heß K, Sauerland C, Bleimüller C, Paulus W, Wölfer J, Stummer W. Long-term survival following additive radiotherapy in patients with atypical
teratoid rhabdoid tumors.
Strahlenther Onkol. 2016 Aug;192(8):569-581. Epub 2016 Jun 7.
Elsayad K, Kriz J, Samhouri L, Haverkamp U, Straeter R, Stummer W, Eich HT. Brain Invasion in meningiomas: Incidence and correlations with clinical variables and prognosis.
World Neurosurg. 2016 Jun 22.
Spille DC, Heß K, Sauerland C, Sanai N, Stummer W, Paulus W, Brokinkel B. Bevacizumab Plus Irinotecan Versus Temozolomide in Newly Diagnosed O6-Methylguanine-DNA Methyltransferase Nonmethylated Glioblastoma: The Randomized GLARIUS Trial.
J Clin Oncol. 2016 Mar 14.
Herrlinger U, Schäfer N, Steinbach JP, Weyerbrock A, Hau P, Goldbrunner R, Friedrich F, Rohde V, Ringel F, Schlegel U, Sabel M, Ronellenfitsch MW, Uhl M, Maciaczyk J, Grau S, Schnell O, Hänel M, Krex D, Vajkoczy P, Gerlach R, Kortmann RD, Mehdorn M, Tüttenberg J, Mayer-Steinacker R, Fietkau R, Brehmer S, Mack F, Stuplich M, Kebir S, Kohnen R, Dunkl E, Leutgeb B, Proescholdt M, Pietsch T, Urbach H, Belka C, Stummer W, Glas M. Intraoperative myelography of traumatic spine injury in patients with ankylosing spondylitis.
Technical note. Acta Neurochir (Wien). 2016 Apr;158(4):745-8.
Schwake M, Zoubi T, Ewelt. Factors confounding fluorescein-guided malignant glioma resections:
edema bulk flow, dose, timing, and now: imaging hardware?
Acta Neurochir (Wien).2016 Feb;158(2):327-8.
Stummer W. Commentary: Combining 5-Aminolevulinic Acid Fluorescence and
Intraoperative Magnetic Resonance Imaging in Glioblastoma Surgery: A
Histology-Based Evaluation.
Neurosurgery. 2016 Apr;78(4):484-6.
Stummer W. hTERT promoter methylation in pituitary adenomas.
Brain Tumor Pathol. 2016 Jan;33(1):27-34.
Köchling M, Ewelt C, Fürtjes G, Peetz-Dienhart S, Koos B, Hasselblatt M,
Paulus W, Stummer W, Brokinkel B. The Value of 5-Aminolevulinic Acid in Low-grade Gliomas and High-grade Gliomas Lacking Glioblastoma Imaging Features: An Analysis Based on Fluorescence, Magnetic Resonance Imaging, 18F-Fluoroethyl Tyrosine Positron Emission Tomography, and Tumor Molecular Factors.
Neurosurgery. 2016 Mar;78(3)
Jaber M, Wölfer J, Ewelt C, Holling M, Hasselblatt M, Niederstadt T, Zoubi T, Weckesser M, Stummer W. Molsidomine for the prevention of vasospasm-related delayed ischemic neurological deficits and delayed brain infarction and the improvement of clinical outcome after subarachnoid hemorrhage: a single-center clinical observational study.
J Neurosurg. 2016 Jan;124(1):51-8.
Ehlert A, Schmidt C, Wölfer J, Manthei G, Jacobs AH, Brüning R, Heindel W,
Ringelstein EB, Stummer W, Pluta RM, Hesselmann V. ADAMTS genes and the risk of cerebral aneurysm.
J Neurosurg. 2016 Jan 8:1-6
Arning A, Jeibmann A, Köhnemann S, Brokinkel B, Ewelt C, Berger K, Wellmann J, Nowak-Göttl U, Stummer W, Stoll M, Holling M.

2015

Factors confounding fluorescein-guided malignant glioma resections: edema bulk flow, dose, timing, and now: imaging hardware?
Acta Neurochir (Wien). 2015 Dec 7.
Stummer W. CD4+ T effector memory cell dysfunction is associated with the accumulation of granulocytic myeloid-derived suppressor cells in glioblastoma patients.
Neuro Oncol. 2015 Nov 17.
Dubinski D, Wölfer J, Hasselblatt M, Schneider-Hohendorf T, Bogdahn U, Stummer W, Wiendl H, Grauer OM. Commentary: Combining 5-Aminolevulinic Acid Fluorescence and Intraoperative Magnetic Resonance Imaging in Glioblastoma Surgery: A Histology-Based Evaluation.
Neurosurgery. 2015 Nov 6.
Stummer W. hTERT promoter methylation in pituitary adenomas.
Brain Tumor Pathol. 2015 Sep 21.
Köchling M, Ewelt C, Fürtjes G, Peetz-Dienhart S, Koos B, Hasselblatt M, Paulus W, Stummer W, Brokinkel B. Fluorescein in brain metastasis and glioma surgery.
Acta Neurochir (Wien). 2015 Dec;157(12):2199-200.
Stummer W. The Value of 5-ALA in Low-grade Gliomas and High-grade Gliomas Lacking Glioblastoma Imaging Features: An Analysis Based on Fluorescence, MRI, 18F-FET PET, and Tumor Molecular Factors.
Neurosurgery. 2015 Sep 11.
Jaber M, Wölfer J, Ewelt C, Holling M, Hasselblatt M, Niederstadt T, Zoubi T, Weckesser M, Stummer W. What is the Surgical Benefit of Utilizing 5-Aminolevulinic Acid for Fluorescence-Guided Surgery of Malignant Gliomas?
Neurosurgery. 2015 Nov; 77(5):663-73.
Hadjipanayis CG, Widhalm G, Stummer W. Altered inhibition in the hippocampal neural networks after spreading depression.
Neuroscience. 2015 Jul 23;304:190-197.
Mesgari M, Ghaffarian N, Khaleghi Ghadiri M, Sadeghian H, Speckmann EJ, Stummer W, Gorji A. Fluorescence in neurosurgery: Its diagnostic and therapeutic use. Review of the literature.
J Photochem Photobiol B. 2015 Jul;148:302-9.
Ewelt C, Nemes A, Senner V, Wölfer J, Brokinkel B, Stummer W, Holling M. Poor man's fluorescence?
Acta Neurochir (Wien). 2015 Sep;157(8):1379-81.
Stummer W. Molsidomine for the prevention of vasospasm-related delayed ischemic neurological deficits and delayed brain infarction and the improvement of clinical outcome after subarachnoid hemorrhage: a single-center clinical observational study.
J Neurosurg. 2015 Jul 10:1-8.
Ehlert A, Schmidt C, Wölfer J, Manthei G, Jacobs AH, Brüning R, Heindel W, Ringelstein EB, Stummer W, Pluta RM, Hesselmann V. δ-Aminolevulinic acid-induced fluorescence-guided resection of brain tumors.
Neurol India. 2015 Mar-Apr;63(2):155-65.
Moiyadi AV, Stummer W. Aminolevulinic acid-mediated photodynamic therapy of human meningioma: an in vitro study on primary cell lines.
Int J Mol Sci. 2015 Apr 30;16(5):9936-48.
El-Khatib M, Tepe C, Senger B, Dibué-Adjei M, Riemenschneider MJ, Stummer W, Steiger HJ, Cornelius JF. Simultaneous fluorescein sodium and 5-ALA in fluorescence-guided glioma surgery.
Acta Neurochir (Wien). 2015
Schwake M et al. A pilot cost-effectiveness analysis of treatments in newly diagnosed high-grade gliomas: the example of 5-aminolevulinic Acid compared with white-light surgery.
Neurosurgery. 2015
Esteves S et al. Proconvulsive effect of hydrochlorothiazide in an in vitro rat seizure model.
Iran J Basic Med Sci. 2014
Kellinghaus C et al Response to journal club: 5-aminolevulinic acid-derived tumor fluorescence: the diagnostic accuracy of visible fluorescence qualities as corroborated by spectrometry and histology and postoperative imaging.
Neurosurgery. 2015
Stummer W Teaching the concept of brain death in undergraduate medical education.
J Surg Educ. 2015
Holling M et al CENTER-TBI Participants and Investigators. Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury
(CENTER-TBI): a prospective longitudinal observational study.
Neurosurgery. 2015
Maas AI et al 5-ALA Glioma Study Group. Anatomic features of glioblastoma and their potential impact
on survival.
Acta Neurochir (Wien). 2015
Nestler U et al. Cognitive impairments and neuronal injury in different brain regions of a genetic rat model of absence epilepsy.
Neuroscience. 2015
Jafarian M et al. Anticonvulsant effect of neural regeneration peptide 2945 on pentylenetetrazol-induced seizures in rats.
Neuropeptides. 2015
Sajadian A et al Surgical treatment of lumbosacral pseudarthrosis and spondyloptosis in a patient with neurofibromatosis type 1 and a large lumbar
anterior meningocele. Case report and review of the literature.
J Neurol Surg A Cent Eur Neurosurg. 2015
Brokinkel B, et al. A comparative analysis of MAPK pathway hallmark alterations in pilocytic astrocytomas: age-related and mutually exclusive.[corrected].
Neuropathol Appl Neurobiol. 2015
Brokinkel B, et al.

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2014

Cerebrospinal fluid leakage in Gorham-Stout disease due to dura mater involvement after progression of an osteolytic lesion in the thoracic spine.
Suero Molina EJ, et al. J Neurosurg Spine 2014 Predicting the "usefulness" of 5-ALA-derived tumor fluorescence for fluorescence-guided resections in pediatric brain tumors: a European survey.
Stummer W, et al. Acta Neurochirur (Wien). 2014 Gamma Knife radiosurgery following subtotal resection provides tumor growth control and excellent clinical outcomes in vestibular schwannoma.
Brokinkel B, et al. J Clin Neurosci. 2014 Glioma Tissue Obtained by Modern Ultrasonic Aspiration with a Simple Sterile Suction Trap for Primary Cell Culture and Pathological Evaluation.
Schroeteler J, et al. Eur Surg Res. 2014 [Interdisciplinary neuro-oncology : Part 2: systemic therapy of primary brain tumors.]
Tabatabai G, et al. Nervenarzt. 2014. [Interdisciplinary neuro-oncology : Part 1: diagnostics and operative therapy of primary brain tumors.]
Tabatabai G, et al. Nervenarzt. 2014. Predictive chromosomal clusters of synchronous and metachronous brain metastases in clear cell renal cell carcinoma.
Gutenberg A, et al. Cancer Genet. 2014 Usefulness of 5-ALA (Gliolan®)-derived PPX fluorescence for demonstrating the extent of infiltration in atypical meningiomas.
Wilbers E, et al.
Acta Neurochir (Wien). 2014 Surgical Treatment of Lumbosacral Pseudarthrosis and Spondyloptosis in a Patient with Neurofibromatosis Type 1 and a Large Lumbar Anterior Meningocele. Case Report and Review of the Literature.
Brokinkel B, Schroeteler J, Kasprzak B, Brentrup A, Ewelt C, Stummer W, Klingenhoefer M.
J Neurol Surg A Cent Eur Neurosurg. 2014 May 12. Kinetics of porphyrin fluorescence accumulation in pediatric brain tumor cells incubated in 5-aminolevulinic acid.
Schwake M, Günes D, Köchling M, Brentrup A, Schroeteler J, Hotfilder M, Fruehwald MC, Stummer W, Ewelt C
Acta Neurochir (Wien). 2014 Apr 29. A comparative analysis of MAPK pathway hallmark alterations in pilocytic astrocytomas: Age-related and mutually exclusive.
Brokinkel B, Peetz-Dienhart S, Ligges S, Brentrup A, Stummer W, Paulus W, Hasselblatt M
Neuropathol Appl Neurobiol. 2014 Apr 18. doi: 10.1111/nan.12145. [Epub ahead of print] 5-Aminolevulinic Acid-derived Tumor Fluorescence: The Diagnostic Accuracy of Visible Fluorescence Qualities as Corroborated by Spectrometry and Histology and Postoperative Imaging.
Stummer W, Tonn JC, Goetz C, Ullrich W, Stepp H, Bink A, Pietsch T, Pichlmeier U
Neurosurgery. 2014;74(3): 310-20 Evaluation of post-operative complications associated with repeat resection and BCNU wafer implantation in recurrent glioblastoma.
Samis Zella MA, Wallocha M, Slotty PJ, Isik G, Hänggi D, Schroeteler J, Ewelt C, Steiger HJ, Sabel M
Acta Neurochir (Wien). 2014;156(2): 313-23 Spreading depression triggers activity in partially disinhibited neuronal tissues.
Eickhoff M, Kovac S, Shahabi P, Khaleghi Ghadiri M, Dreier JP, Stummer W, Speckmann EJ, Pape HC, Gorji A
Exp Neurol. 2014;253: 1-15

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